2-BUTOXYCARBONYLAMINOPHENYLBORONIC ACID, PINACOL ESTER

2-BUTOXYCARBONYLAMINOPHENYLBORONIC ACID, PINACOL ESTER - Names and Identifiers

Name	(2-BOC-aminophenyl)boronic acid
Synonyms	(2-BOC-aminophenyl)boronic acid 2-n-boc-phenylboronic acid pinacol ester (2-BOC-AMINOPHENYL)BORONIC ACID, PINACOL ESTER 2-BUTOXYCARBONYLAMINOPHENYLBORONIC ACID, PINACOL ESTER 2-T-BUTOXYCARBONYLAMINOPHENYLBORONIC ACID, PINACOL ESTER 2-(TERT-BUTOXYCARBONYLAMINO)PHENYLBORONIC ACID, PINACOL ESTER T-BUTYL N-[2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE-2-YL)PHENYL]CARBAMATE TERT-BUTYL-N-[2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL]-CARBAMATE
CAS	159624-15-4
InChI	InChI=1/C17H26BNO4/c1-15(2,3)21-14(20)19-13-11-9-8-10-12(13)18-22-16(4,5)17(6,7)23-18/h8-11H,1-7H3,(H,19,20)

2-BUTOXYCARBONYLAMINOPHENYLBORONIC ACID, PINACOL ESTER - Physico-chemical Properties

Molecular Formula	C17H26BNO4
Molar Mass	319.2
Density	1.07±0.1 g/cm3(Predicted)
Melting Point	96-100°C(lit.)
Boling Point	383.4±25.0 °C(Predicted)
Flash Point	185.7°C
Vapor Presure	4.4E-06mmHg at 25°C
pKa	14.00±0.70(Predicted)
Storage Condition	2-8°C
Refractive Index	1.504
MDL	MFCD03411943

2-BUTOXYCARBONYLAMINOPHENYLBORONIC ACID, PINACOL ESTER - Risk and Safety

WGK Germany

2-BUTOXYCARBONYLAMINOPHENYLBORONIC ACID, PINACOL ESTER - Introduction

(2-BOC-aminophenyl)boronic acid is an organic compound with the chemical formula C12H17BN2O4. It has the following properties:

1. Appearance: colorless or light yellow solid.
2. Melting Point: about 120-123 degrees Celsius.
3. Solubility: Soluble in organic solvents such as methanol, ethanol and dichloromethane.

(2-BOC-aminophenyl)boronic acid is mainly used as follows:

1. Organic synthesis: It is often used as an important raw material and intermediate in organic synthesis, and can be used to synthesize a variety of organic compounds.
2. Pharmaceutical field: it can be used as an important catalyst in the synthesis and modification of drug molecules.

The method of preparing (2-BOC-aminophenyl)boronic acid is as follows:

A common method of synthesis of this compound is by introducing a Boc protecting group in a Phenylboronic acid ester. The specific operation is as follows:
1. In the appropriate solvent, add Phenylboronic acid which ester.
2. Dimethylformamide (DMF) is added as a mixture of solvent and base (e. G. Triethylamine).
3. Add a Boc-amino group (e. G., ethyl Boc-aminoacetate).
4. The reaction mixture is stirred at an appropriate temperature for a period of time to allow the reaction to proceed.
5. The solid was filtered and the product was obtained by concentrating the solvent.

Regarding safety information,(2-BOC-aminophenyl)boronic acid is a chemical and should follow correct operating and safety regulations. Here are some relevant security measures:

1. Avoid inhalation: avoid inhalation or exposure to aerosols, dust or vapors during operation. Wear a suitable protective mask or mask if necessary.
2. Avoid contact with the skin: should avoid direct contact with the skin, if there is contact, please rinse immediately with plenty of water.
3. Avoid contact with eyes: If accidentally splashed into the eyes, please immediately rinse with plenty of water, and medical treatment.
4. Storage and handling: chemicals should be stored in a dry, well-ventilated place, and away from fire and oxidizing agents.

However, it should be noted that this is only a general safety precaution. Please follow the specific chemical safety data sheet and operating instructions.

Last Update：2024-04-09 20:02:46